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KMID : 1134820080370030294
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Journal of the Korean Society of Food Science and Nutrition
2008 Volume.37 No. 3 p.294 ~ p.301
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Protection and Detoxification Effects of Oriental Herb Extract
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Hwang Jin-Kook
Lee Kyung-Jin
Yang Hee-Jin
Park Ki-Moon
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Abstract
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This study was carried out to investigate the protective effects and detoxification of oriental herb extracts
mixture (Saururus chinensis, Taraxacum platycarpum, Ulmus macrocarpa, Glycyrrhiza glabra, Rhynchosia
nulubilis) on TCDD-induced oxidative stress. Thirty five male rats were divided into 5 groups: normal control
group received saline; vehicle control group received DMSO and acetone; only TCDD-treated group received
multiple intraperitoneal injection of TCDD (100 μg/kg) and saline; post-treated group of OHEM (400
mg/kg/day) received oral administration for 5 weeks after TCDD treatment; and pre-treated group of OHEM
(400 mg/kg/day) received oral administration for 6 weeks from 1 week before TCDD treatment. The elevated
serum activities of alanine transaminase (AST), aspartate transaminase (ALT), alkaline phosphatase (ALP),
lactate dehydrogenase (LDH) and atherorganic index due to TCDD were significantly decreased by the treatment
of OHEM (p<0.05); the pre-treatment of OHEM was especially effective. Hydropic lesions and cytoplasmic
vacuolizations in the liver of TCDD-treated rats were inhibited by the treatment of OHEM. Also, OHEM
treatment reduced edemas in small intestine villus of TCDD-treated rats. These results suggest that OHEM
from various oriental herb extracts might be a useful protective and detoxification agent against TCDD.
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KEYWORD
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detoxification, TCDD, dioxin, oriental herb
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